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Our site is currently under construction but in the meantime here's a little bit about us and some images from our amazing technology!
Who We Are and What Our Mission Is
Light microscopy remains one of the rare technologies that has been largely unmodified for over 200 years. Although a central technique in cancer diagnostics and pathology, until recently it has been based on optical designs dating from the 18th-century. Moreover, these outdated microscopes require patient specimens to be prepared as thin, stained sections on glass slides, a process that itself has not changed significantly since the end of the 19th-century.
Following excision of the tissue specimen from the patient, it can take anywhere from four hours to several days to have slides available for review by a pathologist. That multi-step process is illustrated below; it involves hazardous chemicals, expensive and specialized resources, and highly skilled and scarce technical personnel. At a cost of $7 to $40 per slide, and over 300 million slides prepared in the US annually, that is an impact of several billion dollars to the US healthcare system.
Based on IP developed jointly at Lawrence Livermore and UC Davis, the MUSE (Microscopy with Ultraviolet Sectioning Excitation) Microscope uses short-wavelength UV light which penetrates only microns-deep into tissue eliminating the need for precision-cut, thin specimens and even slides. In addition, short-wavelength UV light excites many fluorescent dyes simultaneously, for snap-shot color images. The result is stunning detailed images conveying a degree of resolution, structure and depth unachievable until now by any single technology
Sample preparation is simplified from hours to minutes with a process that does not required trained personnel, organic solvents or related expense. The technique does not alter samples, is non-destructive and thus preserves valuable tissue for molecular studies. Moreover, MUSE Microscope images offer a large field of view for whole-slide-like digital imaging capability and can be easily and quickly formatted through application software to provide familiar, H&E appearance, with diagnostic-quality, subcellular detail to allow easy transition for pathologists used to viewing standard slides.
MUSE microscopy also combines the features and capabilities of a number of imaging technologies, including the detailed morphology of bright-field microscopes, the specificity of fluorescence microscopy and scanning electron microscopy (SEM). Here's a small gallery of the images MUSE can capture:
Renal artery with internal and external elastic lamina
KidneyŚ Image as captured
Normal colon adjacent to cancer. Still in fluorescence mode
Normal breast tissue: Visualization of blood vessels in fat
welcome your interest, questions and thoughts on what we believe to be a very
compelling scientific and commercial opportunity. For more information or to
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